Major Women’s Health Concerns After the Age of 40
After the age of 40, the female body goes through a phase of important physiological and hormonal changes that may affect overall well-being, reproductive health, and quality of life.
Among the most common concerns are:
- a gradual reduction in ovarian reserve
- hormonal fluctuations and changes in hormonal balance
- irregular menstrual cycles
- increased oxidative stress
- physical and mental fatigue
- greater difficulty conceiving
At this stage of life, prevention, a healthy lifestyle and targeted nutritional support become essential—always to be evaluated alongside medical advice.
Interview with Prof. Ermanno Greco
Prof. Ermanno Greco is one of Italy’s leading experts in reproductive medicine, with extensive experience in the assessment and management of female and couple fertility concerns.
His approach integrates clinical evaluation, functional nutrition and personalized supplementation, with particular attention to the different stages of a woman’s life.
Professor, why is targeted supplementation important after the age of 40?
Prof. Greco: “After 40, there is a natural decline in ovarian efficiency and a rise in oxidative stress. Supplementation does not replace medical treatments, but it may support specific physiological processes, such as cellular metabolism, oocyte quality and hormonal balance.”
Female fertility after 40: what are the main factors to consider?
Prof. Greco: “Age influences oocyte quality and cellular energy pathways. Micronutrients, antioxidants and compounds involved in mitochondrial metabolism may help support residual reproductive function.”
RIFERTOSAN DONNA, a dietary supplement formulated for female fertility, featuring vitamins, inositol, betaine, resveratrol, coenzyme Q10 and selenium.
And what about metabolism and microcirculation?
Prof. Greco: “Adequate microcirculation and healthy cellular metabolism are essential for reproductive well-being. Certain amino acids play a key role in supporting these mechanisms.”
ARGISOL, an arginine-based dietary supplement that helps provide an additional intake of this amino acid, particularly within female fertility pathways and metabolic support programs.
An Integrated and Personalized Approach to Women’s Health
According to Prof. Greco, when properly selected, dietary supplementation can represent a valuable support within women’s health pathways after 40.
The key concept is personalization: there is no “one-size-fits-all” solution, but rather different options for different needs.
After 40, choices should take into account:
- biological age
- personal medical history
- lifestyle
- reproductive goals
- stress levels and oxidative load
Always under medical supervision.
Taking care of your well-being after 40 means acting consciously through prevention, regular check-ups and appropriate nutritional support.
When properly implemented, dietary supplementation can become a valuable long-term ally for women’s health.






